Sparfosic acid trisodium
英文名称:Sparfosic acid trisodium
CAS号:70962-66-2
分子式:C6H11NNaO8P
分子量:279.12
EINECS号:
Mol文件:70962-66-2.mol
Sparfosic acid trisodium 性质
| 储存条件 | Store at -20°C |
|---|---|
| 形态 | 固液混合物 |
| 颜色 | 无色至类白色 |
| 水溶解性 | Water: 250 mg/mL (778.67 mM) |
Sparfosic acid trisodium 用途与合成方法
Sparfosic acid trisodium 是天门冬氨酸氨甲酰转移酶 (aspartate transcarbamoyl transferase) 的有效抑制剂，具有抗肿瘤和抗代谢物活性。天冬氨酸氨甲酰转移酶催化第二步 de novo 嘧啶生物合成。
Sparfosic acid (PALA) treatment causes apoptosis in the resistant Br1 cells.
Sparfosic acid (PALA, 300 µM) shows progressive accumulation of cells in S phase and activation of an apoptotic pathway leading to cell death.
Cell Cycle Analysis
| Cell Line: | Br-l and L-2 cell lines established from metastasis in nude mouse injected with the human tumor cell line MDA-MB-435. |
| Concentration: | 300 µM. |
| Incubation Time: | 12, 24 and 48 h. |
| Result: | Cells were predominantly in S phase in both the cell lines, although slightly higher proportion of cells in S phase were noted in L-2 than Brl-3prl cells. |
Western Blot Analysis
| Cell Line: | Br-l and L-2 cell lines. |
| Concentration: | 300 µM. |
| Incubation Time: | 4, 10 and 24 h. |
| Result: |
There was moderate difference in the level of phosphorylated Rb proteins seen in the two cell types.
Marked increase in the amount of cyclin A protein was detected in the L-2 cells undergoing apoptosis with the highest level detected at 10 h post-drug treatment. In contrast, there was no increase in the level of cyclin A seen in the Brl-3prl cells. Cyclin E protein was found elevated in the L-2 cells and Brl-3prl cells compared to their respective controls. |
Sparfosic acid trisodium 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-112732B | 70962-66-2 | 1 mg | 1280 | |
| 2026-06-05 | HY-112732B | Sparfosic acid trisodium | 70962-66-2 | 5mg | 3200 |
Sparfosic acid trisodium供应商 更多
ChemeGen 中国
联系电话： 18818260767
产品介绍：
英文名称：N-phosphonacetyl-L-aspartate trisodium
CAS：70962-66-2
纯度：98%
包装信息：10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注：品牌：ChemeGen
TargetMol中国（陶术生物）
联系电话：4008200310 15002144251
产品介绍：
中文名称：Sparfosic acid 三钠盐
英文名称：Sparfosic acid trisodium
CAS：70962-66-2
包装信息：1mg/RMB 1099;5mg/RMB 3799
南通全益生物科技有限公司
联系电话：0513-66337626 18051384581
产品介绍：
英文名称：Sparfosic acid trisodium
CAS：70962-66-2
纯度：98%+ HPLC
包装信息：10mg，500mg，1g，2g，5g，10g，more
上海一飞生物科技有限公司
联系电话：021-65675885 18964387627
产品介绍：
英文名称：Sparfosic acid trisodium
CAS：70962-66-2
纯度：95%
包装信息：2mg;5mg;25mg
备注：试剂级
上海陌孚医药科技有限公司
联系电话：4000862158 18117107507
产品介绍：
英文名称：Sparfosic acid trisodium
CAS：70962-66-2
纯度：>=99%
包装信息：10mg;100mg;500mg;200mg;10mM*1mLinDMSO;50mg;5mg
