Sapienic acid (minimum bactericidal concentrations (MBCs) range, 31.3 to 375.0 μg/mL) is active against
Streptococcus sanguinis
,
Streptococcus mitis
, and
Fusobacterium nucleatum
but not active against
Escherichia coli
,
Staphylococcus aureus
,
S. marcescens
,
P. aeruginosa
,
Corynebacterium bovis
,
Corynebacterium striatum
, and
Corynebacterium jeikeium
(MBC > 500 μg/mL). Kinetic assays show that killing of
S. sanguinis
and
S. mitis
with sapienic acid is gradual and occurred within 24 h.
