HYDRIDO(DIMETHYLPHOSPHINOUS ACID-KP)[HYDROGEN BIS(DIMETHYLPHOSPHINITO-KP)]PLATINUM (II)

Widely used in complex multi-step organic syntheses. This mild hydration catalyst converts hindered and acid/base sensitive nitriles to amides. The amide is released from the metal coordination sphere preventing further hydrolysis to acid. Typically, turnover frequency (TOF) ranges from 16 to 380 h-1 depending on steric factors. For optimal results avoid the presence of coordinating anions especially cyanide and halide.

Parkins’ Catalyst promotes the efficient nitriles hydration to amides by the phosphine oxide addition to nitrile.