Severe acute respiratory syndrome coronavirus (SARS-CoV) nucleocapsid protein is a viral protein encoded by the N gene in SARS-CoV RNA.1 SARS-CoV is a member of the Betacoronavirus genus of viruses and has an approximately 79% sequence identity with SARS-CoV-2, the causative agent of COVID-19.2,3 The SARS-CoV nucleocapsid protein has a greater than 90% similarity to the SARS-CoV-2 nucleocapsid protein, and SARS-CoV-2 contains 27 T cell epitopes that are identical to SARS-CoV T cell epitopes.4 The SARS-CoV nucleocapsid protein packages the viral RNA into a helical ribonucleoprotein complex (RNP) that is a template for viral replication.5 It is integral for viral self-assembly and involved with regulation of the cell cycle. SARS-CoV is the causative agent of SARS, a primarily respiratory illness characterized by fever, cough, shortness of breath, and an approximately 10% fatality rate.3 Cayman’s SARS-CoV Nucleocapsid Protein Polyclonal Antibody can be used for ELISA.WARNING This product is not for human or veterinary use.
