(E)-cyclooct-4-enol / axial - TCO4 / A

(R)-TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. (R)-TCO-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Alkyl-Chain

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005