CB1151
CB1151 性质
| 沸点 | 601.5±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.07±0.1 g/cm3(Predicted) |
| 储存条件 | 4°C, protect from light, stored under nitrogen |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 14.43±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
CB1151 用途与合成方法
IC50: 0.82 nM
CB1151 (0-100 nM; 5 days) inhibits MCF-7 cells growth, this cell proliferation is accessed by [ 3 H]-thymidine incorporation, exhibits an IC 50 value of 0.82 nM. CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element with a EC 50 of 1.2 nM, the activation of IP9-type VD response elements shows a good correlation with inhibition of proliferation than the activation of DR3-type elements (EC 50 =3.2nM) in MCF-7 cells transfected with the CAT reporter. CB1151 shows a functional dissociation constant (K df ) value of 3.6 nM. The ligand concentration that provides 50% of protease-resistant VDR fragment is defined by K df , this is different from that of the traditional dissociation constant (K d ).
Cell Proliferation Assay
| Cell Line: | MCF-7 cell |
| Concentration: | 0 nM; 0.1nM; 0.5nM; 0.8nM; 1nM; 5nM; 10 nM |
| Incubation Time: | 5 days |
| Result: | Inhibits MCF-7 cells growth. |
