STAT5-IN-2
中文名称:STAT5-IN-2
英文名称:STAT5-IN-2
CAS号:2111834-61-6
分子式:C26H27N3O
分子量:397.51
EINECS号:
Mol文件:2111834-61-6.mol
![STAT5-IN-2 结构式](https://img.chemicalbook.com/CAS/20200611/GIF/2111834-61-6.gif)
STAT5-IN-2 性质
沸点 | 635.5±55.0 °C(Predicted) |
---|---|
密度 | 1.160±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:100 mg/mL(251.57 mM;需要超声波) |
酸度系数(pKa) | 16.56±0.30(Predicted) |
形态 | 固体 |
颜色 | 米白色至浅黄色 |
STAT5-IN-2 用途与合成方法
STAT5-IN-2 是 STAT5 的抑制剂,在 K562 和 KU812 细胞中的 EC50 分别为 9 μM和 5 μM,在文献 1 的名称是 17f。STAT5-IN-2 具有高效的抗白血病活性。
STAT5 9 μM (EC 50 , in K562 cells) |
STAT5 5 μM (EC 50 , in KU812 cells ) |
STAT5-IN-2 has EC
50
values of 9 μM and 5 μM in K562 and KU812 cells, respectively.
STAT5-IN-2 (100 nM-50 µM; 48 hours) has EC
50
values of 2.6 µM and 3.5 µM in KG1a and MV-4-11 cells, respectively.
STAT5-IN-2 (10 µM; 48 hours) induces apoptosis in all cell lines (K562, KU812, KG1a and MV-4-11 cells).
STAT5-IN-2 (10 µM; 24 hours) blocks phosphorylation of STAT5.
Cell Viability Assay
Cell Line: | KG1a and MV-4-11 cell lines |
Concentration: | 100 nM, 10 µM, 20 µM, 30 µM, 40 µM, 50 µM |
Incubation Time: | 48 hours |
Result: | Inhibited cell growth in KG1a and MV-4-11 cell lines |
Apoptosis Analysis
Cell Line: | K562, KU812, KG1a and MV-4-11 cells |
Concentration: | 10 µM |
Incubation Time: | 48 hours |
Result: | Significantly increased the number of apoptotic cells. |
Western Blot Analysis
Cell Line: | KG1a, MV-4-11 and KU812 cells |
Concentration: | 10 µM |
Incubation Time: | 24 hours |
Result: | Inhibited phosphorylation of STAT5 compared to no influence on phosphorylation level of STAT3, Akt and Erk1/2. |
STAT5-IN-2 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-04-30 | HY-102048 | 1 mg | 1310 | ||
2024-04-30 | HY-102048 | STAT5-IN-2 | 2111834-61-6 | 5mg | 3013 |
STAT5-IN-2供应商 更多
杭州畅存生物科技有限公司
联系电话:0571-; 13567100326
产品介绍:
英文名称:STAT5-IN-2
CAS:2111834-61-6
纯度:98%HPLC
包装信息:100mg/;1g/;5g/;10g/
上海瀚香生物科技有限公司
联系电话:17754423994 17754423994
产品介绍:
英文名称:STAT5-IN-2
CAS:2111834-61-6
纯度:98% HPLC LCMS
包装信息:100mg;500mg;1g
备注:现货,仅供科研用途
北京普西唐生物科技有限公司
联系电话:010-60605840 18892239720
产品介绍:
英文名称:STAT5-IN-2
CAS:2111834-61-6
纯度:98%
包装信息:5mg;10mg;25mg;50mg;100mg
上海源溪生物科技有限公司
联系电话:021-58447131 13564518121
产品介绍:
英文名称:STAT5 inhibitor 17f
CAS:2111834-61-6
纯度:98% HPLC
包装信息:100mg,250mg,1g