CD2AP is a scaffolding protein that is thought to link membrane proteins to the cytoskeleton. It plays a role in formation of tight junctions in specialized cell types such as the slit diaphragm in the kidney glomerulus. CD2AP is also involved in the immunological synapse between CD2 expressing T cells and antigen presenting cells. It has been shown that interaction between CD2AP and other cytoskeletal proteins may regulate the endocytosis of EGFR.
[1] Kirsch, K.H. et al. (1999) Proc. Natl. Acad. Sci. USA 96, 6211-6216.
[2] Kirsch, K.H. et al. (2001) J. Biol. Chem. 276, 4957-4963.
[3] Lynch, D.K. et al. (2003) J. Biol. Chem. 278, 21805-21813.
[4] Kawachi, H. et al. (2006) Nephrology (Carlton) 11, 274-281.
[5] Hutchings, N.J. et al. (2003) J. Biol. Chem. 278, 22396-22403.
