Prostaglandin F Receptor Reporter Assay Kit

Prostaglandin F_2α (PGF_2α) is a biologically important prostanoid that exerts its actions through binding to the PGF_2α receptor (FP). PGF_2α is synthesized in many tissues, including the eye and organs of the female reproductive system. Activation of ocular FP receptors via agonists such as bimatoprost and travoprost reduces ocular hypertension. Antagonism of the FP receptor inhibits uterine contraction and delays parturition in rodent models, while knockout of the receptor inhibits parturition in mice, an effect that can be restored through ovariectomy during pregnancy. FP receptor antagonism also decreases endometriosis-like lesions and reduces cell proliferation and angiogenesis in a nude mouse endometrial xenograft model. In addition, FP receptor knockout increases neurological deficits and lesion volume in mice following intracerebral hemorrhagic stroke. These findings highlight the importance of the FP receptor in reproductive and neurological disorders and emphasize the need for continued research and drug discovery in these areas.

[1] AARON N. HATA  Richard M B. Pharmacology and signaling of prostaglandin receptors: Multiple roles in inflammation and immune modulation[J]. Pharmacology & Therapeutics, 2004, 103 2: Pages 147-166. DOI: 10.1016/j.pharmthera.2004.06.003
[2] OLIVER POHL. OBE022, an Oral and Selective Prostaglandin F2α Receptor Antagonist as an Effective and Safe Modality for the Treatment of Preterm Labor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2018, 366 2: 349-364. DOI: 10.1124/jpet.118.247668
[3] YUKIHIKO SUGIMOTO. Failure of Parturition in Mice Lacking the Prostaglandin F Receptor[J]. Science, 1997, 277 5326. DOI: 10.1126/science.277.5326.681
[4] SYED FURQUAN AHMAD A W H Ali Akoum. Selective modulation of the prostaglandin F2α pathway markedly impacts on endometriosis progression in a xenograft mouse model.[J]. Molecular human reproduction, 2015: 905-916. DOI: 10.1093/molehr/gav056
[5] SHEKHER MOHAN. Genetic Deletion of PGF2α-FP Receptor Exacerbates Brain Injury Following Experimental Intracerebral Hemorrhage.[J]. Frontiers in Neuroscience, 2018: 556. DOI: 10.3389/fnins.2018.00556