Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)

Amyloid-β (1-28) (Aβ28) is a synthetic peptide that lacks 14 C-terminal amino acids and is more soluble than Aβ42 (Item No. 20574).1 Aβ28 forms fibrils and plaques in vitro that are similar to those formed by Aβ42 and induces learning deficits in a passive avoidance task in rats.2,3,4WARNING This product is not for human or veterinary use.

[1] CHRISTOPHER D SYME. Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer’s disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques.[J]. The Journal of Biological Chemistry, 2004, 279 18: 18169-18177. DOI: 10.1074/jbc.m313572200
[2] D A KIRSCHNER. Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 19: 6953-6957. DOI: 10.1073/pnas.84.19.6953
[3] D BURDICK. Assembly and aggregation properties of synthetic Alzheimer’s A4/beta amyloid peptide analogs.[J]. The Journal of Biological Chemistry, 1992, 267 1: 546-554.
[4] X A ALVAREZ. Intrahippocampal injections of the beta-amyloid 1-28 fragment induces behavioral deficits in rats.[J]. Methods and findings in experimental and clinical pharmacology, 1997, 19 7: 471-479.