Lepidiline A

Lepidiline A exhibits cytotoxic activity against HL-60 cells with an IC50 value of 32.3 μM. Lepidiline A targets HSD17B1 activity, increases the bioconversion efficiency of sex hormones (including the conversion of estrogen into 17β-estradiol and 4-androsten-3,7-dione into testosterone), thereby improving the reproductive capacity of fruit flies.[1][2].

[1] Mlostoń G, et al. Synthesis and Cytotoxic Activity of Lepidilines A-D: Comparison with Some 4,5-Diphenyl Analogues and Related Imidazole-2-thiones. J Nat Prod. 2021 Nov 22. DOI:10.1021/acs.jnatprod.1c00797
[2] Cheng C, et al. Lepidiline A Improves the Balance of Endogenous Sex Hormones and Increases Fecundity by Targeting HSD17B1. Mol Nutr Food Res. 2020 May;64(10):e1900706. DOI:10.1002/mnfr.201900706