NS 309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels.
Positive modulator of small- and intermediate- conductance Ca 2+ -activated K + channels (SK and IK channels); increases Ca 2+ sensitivity. Displays no activity at BK channels.
NS309 is a Ca2+-activated IK/SK potassium channel activator.
NS309 (2 mg/kg; i.p.) protects against SCI/R in rabbits[6].
| Animal Model: | Adult New Zealand white rabbits (2.5-3.0 kg)[6] |
| Dosage: | 2 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Significantly improved neurological outcome of SCI/R challenged rabbits. |
