基本属性 生物活性靶点体外研究体内研究 用途与合成方法 MSDS L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE 价格(试剂级) 供应商 供应信息

L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE

L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE

英文名称:CA-074
CAS号:134448-10-5
分子式:C18H29N3O6
分子量:383.44
EINECS号:200-258-5
Mol文件:134448-10-5.mol
L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE 结构式

L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE 性质

沸点 728.9±60.0 °C(Predicted)
密度 1.267±0.06 g/cm3(Predicted)
储存条件 -20°C
溶解度 溶于甲醇,浓度为 1mg/ml。也溶于DMSO或乙醇。
形态 固体
酸度系数(pKa) 3.43±0.20(Predicted)
颜色 白色至黄色

L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE 用途与合成方法

CA-074是组织蛋白酶B (cathepsin B) 的有效抑制剂, Ki 值为2 to 5 nM。

Ki: 2 to 5 nM (Cathepsin B)

CA-074 is a synthetic analogue of E-64, a natural peptidyl epoxide that irreversibly inhibits most known lysosomal cysteine proteinases, and is developed by means of rational drug design, exploiting the dipeptidylcarboxypeptidase activity of cathepsin B. CA-074 can be used to selectively inhibit cathepsin B within living cells, as long as the experimental conditions permit significant fluid-phase endocytosis of the drug. CA-074 inhibits cathepsin B with a K i of 2 to 5 nM, whereas the initial K i s for cathepsin H and L are about 40-200 μM. CA-074 exhibits 10000-30000 times greater inhibitory effects on purified rat cathepsin B than on cathepsin H and L.

Intraperitoneally injection of compound CA-074 into rats potently and selectively inhibits cathepsin B activity. Intravenously administration of CA-074 immediately after the ischaemic insult saves 67% of CA1 neurons from delayed neuronal death on day 5 in eight monkeys undergoing 20 min brain ischaemia: the extent of inhibition is excellent in three of eight and good in five of eight monkeys.

安全信息

WGK Germany3

MSDS信息

语言:English
提供商:SigmaAldrich

L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 HY-103350 L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE 134448-10-5 1mg 900
2024-11-08 HY-103350 L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE 134448-10-5 10mM * 1mLin DMSO 2278

L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE供应商 更多

张家港阿拉宁生化技术有限公司
联系电话:0512-58900862 400-0707518
产品介绍:
英文名称:CA-074
CAS:134448-10-5
纯度:>98% HPLC
包装信息:5mg; 25mg; 100mg; 1g; 5g; 25g;100g
备注:Peptide
吉尔生化(上海)有限公司
联系电话:21-61263452 13641803416
产品介绍:
英文名称:L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide
CAS:134448-10-5
纯度:95% HPLC,98% HPLC
包装信息:10mg, 25mg, 50mg, 100mg, 500mg, 1g,10g
上海瀚鸿科技股份有限公司
联系电话:021-54306202 13764082696
产品介绍:
英文名称:L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide
CAS:134448-10-5
备注:123P01
广州爱纯医药科技有限公司
联系电话:020-39119399 18927568969
产品介绍:
英文名称:CA-074
CAS:134448-10-5
纯度:>=99% (TLC)
包装信息:5Mg;10Mg;25Mg;50Mg;100Mg;1g;5g;10g;25g
备注:品牌:StdSun | 提供定制合成服务(包括:小分子,药物杂质及医药中间体)
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
联系电话:021-61415566 800-8193336
产品介绍:
英文名称:CA-074
CAS:134448-10-5
纯度:>=99% (TLC)
包装信息:5MG
备注:C5732-5MG

最新发布供应信息

cathepsin B抑制剂(CA-074)
上海泽叶生物科技有限公司 2024-11-22
134448-10-5CA 074
上海嘉定区澄浏公路52号 2024-11-22