Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. Among the BMPs, BMP-2 has bone and cartilage inducing abilities. The other important functions of BMP-2 are in heart formation. BMP-2 signaling also involves active cross talk with major pathways such as Smad, MAPK, PI3K and NF-κ B.. Monoclonal Anti-BMP-2 recognizes recombinant BMP-2. It also detects BMP-4 (25% cross reactivity).
