THP-SS-alcohol is a cleavable linker contains a THP alcohol protecting group and a disulfide bond. The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent. The THP protecting group can be removed under acidic conditions.
THP-SS-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Disulfide Cleavable Linker; Cleavable Linker
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:
10.1038/nrd.2016.268
