Diethyl Ethoxymagnesiomalonate

Diethyl Ethoxymagnesiomalonate is used for synthesis of acyl malonates^[1] or methyl ketones^[2].

Diethyl Ethoxymagnesiomalonate is prepared from Diethyl Malonate, Magnesium, ethanol, and a catalytic amount of CCl4.

Diethyl Ethoxymagnesiomalonate is typically prepared and used immediately as a solution in solvents such as ether or benzene. The reagent is moisture sensitive; best yields are obtained when the reagent is used under anhydrous conditions.

1. (a) Lund, H.; Voigt, A. OSC 1943, 2, 594. (b) Price, J. A.; Tarbell, D. S. OSC 1963, 4, 285. (c) Meyer, K.; Bloch, H. S. OSC 1955, 3, 637. (d) Hormi, O. OS 1987, 66, 173.
2. (a) Reynolds, G. A.; Hauser, C. R. OSC 1963, 4, 708. (b) Ghatak, U. R.; Sanyal, B.; Ghosh, S.; Sarkar, M.; Raju, M. S.; Wenkert, E. JOC 1980, 45, 1081. (c) Chatterjea, J. N.; Sahai, R.; Swaroopa, B. B.; Bhakta, C.; Jha, H. C.; Zilliken, F. CB 1980, 113, 3656. (d) Kruger, G.; Keck, J.; Noll, K.; Pieper, H. AF 1984, 34, 1612. (e) Dasgupta, R.; Kanjilal, P. R.; Patra, S. K.; Sarkar, M.; Ghatak, U. R. T 1985, 41, 5619. (f) McKinnon, D. M.; Abouzeid, A. JHC 1991, 28, 347. (g) Singh, B. JHC 1991, 28, 881.