U-
46619 is the consensus stable analog of prostaglandin H
2/thromboxane A
2 (PGH
2/TXA
2) and has been used as a TXA
2 agonist in pharmacologic studies for several decades.
1 There have been several hypotheses put forward by scientists studying ω-
3 fatty acids stipulating that the agonist activity of TXA
3 was substantially different than that of TXA
2.
2 However, no stable analogs of TXA
3 were available to test these theories. Δ
17-
U-
46619 is the first direct, stable analog of TXA
3 ever synthesized. There are no published reports on its activity to date.
