(±)9(10)-EpOME-d4

(±)9,10-EpOME-d4 is intended for use as an internal standard for the quantification of (±)9(10)-EpOME (Item No. 52400) by GC- or LC-MS. (±)9(10)-EpOME is the 9,10-cis epoxide of linoleic acid (Item No. 90150), generated by neutrophils during the oxidative burst.1 It has been recovered from the lungs of hyperoxic rats and from humans with acute respiratory distress syndrome.2 Mitochondrial dysfunction is the main feature of (±)9(10)-EpOME cytotoxicity, which may be due to the diol metabolites as well as the parent epoxide.3,4WARNING This product is not for human or veterinary use.

[1] MIKA HAYAKAWA . Neutrophils biosynthesize leukotoxin, 9, 10-epoxy-12-octadecenoate[J]. Biochemical and biophysical research communications, 1986, 137 1: Pages 424-430. DOI: 10.1016/0006-291x(86)91227-1
[2] TAKAYUKI OZAWA . Biosynthesis of leukotoxin, 9, 10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxia[J]. Biochemical and biophysical research communications, 1986, 134 3: Pages 1071-1078. DOI: 10.1016/0006-291x(86)90360-8
[3] K KOSAKA. Leukotoxin, a linoleate epoxide: its implication in the late death of patients with extensive burns.[J]. Molecular and Cellular Biochemistry, 1994, 139 2: 141-148. DOI:10.1007/BF01081737.
[4] JEFFERY H. MORAN . Cytotoxicity of Linoleic Acid Diols to Renal Proximal Tubular Cells[J]. Toxicology and applied pharmacology, 1997, 146 1: Pages 53-59. DOI: 10.1006/taap.1997.8197