Dihydropleuromutilin is a semisynthetic antibiotic and derivative of pleuromutilin . It is active against S. aureus, M. hominis, M. gallisepticum, and M. hyorhinis bacteria (MICs = 0.5, 0.3, 0.3, and 2 μg/ml, respectively).
Dihydropleuromutilin is a semi-synthetic pleuromutilin formed by selective reduction of the ethene to ethyl. Dihydropleuromutilin exhibits comparable antibiotic potency to pleuromutilin. Extensive studies have been undertaken on semi-synthetic dihydropleuromutilin analogues but the parent compound has received only limited attention.
