NSC 46633

2-Acetyl-6-methylphenol is used to prepare (hydroxyphenyl)(piperidinyl)pyridines as IκB kinase β inhibitors and orally active anti-inflammatory agents.

Preparation by reaction of acetic acid on o-cresol with zinc chloride at reflux (Nencki reaction) (20%).

[1] Patent: US2014/349990, 2014, A1. Location in patent: Paragraph 0739; 0740
[2] Patent: WO2014/191896, 2014, A1. Location in patent: Page/Page column 147
[3] Organic and Biomolecular Chemistry, 2015, vol. 13, # 36, p. 9418 - 9426
[4] Patent: WO2014/191894, 2014, A1. Location in patent: Page/Page column 104; 105