Methyl 2,6-dichloro-4-cyanobenzoate

409127-31-7

409127-32-8

Step a: Synthesis of methyl 2,6-dichloro-4-cyanobenzoate Methyl 4-carbamoyl-2,6-dichlorobenzoate (100 mg, 0.4 mmol) was dissolved in pyridine (2 mL) and trifluoroacetic anhydride (0.11 mL, 0.8 mmol) was added slowly and dropwise at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. Upon completion of the reaction, the mixture was poured into pre-cooled ice water, the precipitated solid was filtered, washed thoroughly with cold water and dried to afford methyl 2,6-dichloro-4-cyanobenzoate (55 mg, 88% yield) as an off-white solid.