1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE

基本属性生物活性靶点体外研究体内研究用途与合成方法 1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE 价格(试剂级) 供应商供应信息相关产品

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE

中文名称:1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE

英文名称:1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE

CAS号:353791-85-2

分子式:C30H37Cl2IN2O2

分子量:655.44

EINECS号:

Mol文件:353791-85-2.mol

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE 结构式

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE 性质

储存条件	Store at +4°C
溶解度	在 DMSO 中溶解度为 100 mM，在乙醇中溶解度为 50 mM
形态	粉末
颜色	浅黄至黄色

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE 用途与合成方法

生物活性

J-113863 是一种有效的选择性的 CCR1 (CD18) 拮抗剂，对人和小鼠 CCR1 受体的 IC50 值分别为 0.9 nM 和 5.8 nM。J-113863 是人 CCR3 的强效拮抗剂 (IC50 为 0.58 nM)，还是小鼠 CCR3 的弱效拮抗剂 (IC50 为 460 nM)。J-113863 对 CCR2，CCR4 和 CCR5 以及 LTB4 或 TNF-α 受体没有活性。抗炎作用。

靶点

CCR1

0.9 nM (IC ₅₀ , Human CCR1)

CCR1

5.8 nM (IC ₅₀ , Mouse CCR1)

CCR3

0.58 nM (IC ₅₀ , Human CCR3)

CCR3

460 nM (IC ₅₀ , Mouse CCR3)

体外研究

Modified Vaccinia virus Ankara (MVA) but not MVA and vaccinia virus (VACV) infected MH-S cells increase the expression of the CXCR2 acting chemokine CXCL2. MH-S cells constitutively produce CCL2 and CCR1 acting chemokines CCL3, CCL5 and CCL9. Consequently, supernatants of mock treated and virus infected MH-S cells induce chemotaxis of murine promyelocyte MPRO cells and human monocytic THP-1 cells at the same level. However, supernatants of MVA infected MH-S cells significantly increase chemotaxis of the CCR2 deficient human monocytic cell line U-937. Chemotaxis of all above cell types is inhibited by J-113863.

体内研究

J-113863 (3-10 mg/kg; intraperitoneal injection; once daily; for 11 days; DBA-1 male mice) treatment improves paw inflammation and joint damage, and dramatically decreases cell infiltration into joints in arthritic mice.

Animal Model:	DBA-1 male mice (10-12 weeks) induced with Collagen
Dosage:	3 mg/kg, 10 mg/kg
Administration:	Intraperitoneal injection; once daily; for 11 days
Result:	Improved paw inflammation and joint damage, and dramatically decreased cell infiltration into joints.

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2024-08-19	HY-103360			1 mg	727
2024-08-19	HY-103360	1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE	353791-85-2	5mg	1600

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE供应商 更多

天津凯利奇生物科技有限公司

现货

联系电话： 15076683720

产品介绍：

英文名称：J113863

CAS：353791-85-2

纯度：≥98%

包装信息：1g,5g,10g,25g根据客户需要分装

备注：Not For Human Use, Lab Use Only.

库存量：2g

现货日期：2024/10/7 18:47:54

电话询单

武汉易泰科技有限公司上海分公司

联系电话：821-50328103-801 18930552037

产品介绍：

英文名称：J 113863;1,4-cis-1-(1-Cycloocten-1-ylMethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]aMino]-1-ethylpiperidiniuMiodide

CAS：353791-85-2

纯度：99% HPLC

包装信息：1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g

电话询单

上海一飞生物科技有限公司

联系电话：021-65675885 18964387627

产品介绍：

英文名称：J 113863

CAS：353791-85-2

纯度：98%

包装信息：1mg;2mg;5mg

备注：试剂级

电话询单

ChemeGen 中国

联系电话： 18818260767

产品介绍：

英文名称：J-113863

CAS：353791-85-2

纯度：98%

包装信息：10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g

备注：品牌：ChemeGen

电话询单

天津普西唐生物医药科技有限公司

联系电话：010-60605840 15801484223;

产品介绍：

英文名称：J-113863

CAS：353791-85-2

纯度：98%

包装信息：5mg

电话询单

"1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE"相关产品信息

吨-9-碳乙酰胺

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE 性质

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE 用途与合成方法

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE 价格(试剂级)

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE供应商 更多

最新发布供应信息

"1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE"相关产品信息

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE供应商更多