1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE

1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis. It inhibits glycogenolysis in isolated liver cells (IC₅₀ = 1.0 μM) and in homogenates of cerebral cortex and cerebellum (IC₅₀s = 463 and 383 nM, respectively). DAB is used to inhibit glycogenolysis, in liver and in brain, in various animal models.

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride has been used as an α-glucosidase (GAA) inhibitor.

1,4-Dideoxy-1,4-imino-D-arabinitol is a naturally occurring pyrrolidine alkaloid. It is found in Arachniodes standishii and Angylocalyx boutiqueanus.

Inhibitor of glycogen phosphorylase and α-glucosidases.

[1] B. ANDERSEN N W. The effect of glucose on the potency of two distinct glycogen phosphorylase inhibitors.[J]. The Ukrainian Biochemical Journal, 2002, 13 1: 443-450. DOI: 10.1042/bj20020153
[2] B. ANDERSEN. Inhibition of glycogenolysis in primary rat hepatocytes by 1, 4-dideoxy-1,4-imino-D-arabinitol.[J]. The Ukrainian Biochemical Journal, 1999, 17 1: 545-550. DOI: 10.1042/bj3420545
[3] ANNE B. WALLS. Characterization of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) as an inhibitor of brain glycogen shunt activity[J]. Journal of Neurochemistry, 2008, 105 4: 1462-1470. DOI: 10.1111/j.1471-4159.2008.05250.x
[4] KELD FOSGERAU . Kinetic and Functional Characterization of 1,4-Dideoxy-1,4-imino-d-arabinitol: A Potent Inhibitor of Glycogen Phosphorylase with Anti-hyperglyceamic Effect in ob/ob Mice[J]. Archives of biochemistry and biophysics, 2000, 380 2: Pages 274-284. DOI: 10.1006/abbi.2000.1930
[5] GIBBS M. Role of Glycogenolysis in Memory and Learning: Regulation by Noradrenaline, Serotonin and ATP[J]. Frontiers in Integrative Neuroscience, 2016, 9 1. DOI: 10.3389/fnint.2015.00070
[6] NEPHTALI MARINA. Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat.[J]. ACS Applied Nano Materials, 2015: 775-783. DOI: 10.1161/hypertensionaha.114.04683