IL-6 is a cytokine with roles in both the initiation and resolution of inflammatory responses.1,2 IL-6 is produced in response to an inflammatory event, induces recruitment of neutrophils to the site of inflammation, and signals through the membrane-bound IL-6 receptor (IL-6R) to upregulate the synthesis of acute phase proteins, lipolysis in the liver, and induced differentiation of T and B cells. Following initiation of this classical signaling pathway, a soluble form of IL-6R (sIL-6R) is released from neutrophils to promote recruitment of monocytes and macrophages, induction of fever via IL-6 action in the hypothalamus, and production of anti-inflammatory M2 macrophages to initiate tissue repair. Production of IL-6 is dysregulated in various chronic inflammatory diseases, including rheumatoid arthritis, Castleman disease, polymyalgia rheumatica, and giant cell arteritis.3 It also induces tumor growth and metastasis via activation of JAK/STAT signaling.4 Cayman's Interleukin-6 Monoclonal Antibody (Clone 19) can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The predicted size of IL-6 is 24 kDa and this antibody recognizes IL-6 at an observed band size of 30 kDa from human samples.WARNING This product is not for human or veterinary use.
