RG33 (trifluoroacetate salt)

RG33 is a 33-amino acid synthetic peptide that corresponds to amino acids 209-219 and 220-241 of the two class Y helices in the C-terminal domain of apolipoprotein A1 (ApoA1).1 It solubilizes multilamellar vesicles (MLVs) containing 1,2-dimyristoyl-sn-glycero-3-PC (DMPC; Item No. 15097) to form recombinant HDL. Lipid-bound RG33 induces cholesterol efflux in J774 macrophages. RG33 (12 mg/kg) decreases blood glucose levels in insulin-resistant mice.WARNING This product is not for human or veterinary use.

[1] SHELLEY J EDMUNDS. A short peptide of the C-terminal class Y helices of apolipoprotein A-I has preserved functions in cholesterol efflux and in vivo metabolic control.[J]. Scientific Reports, 2020: 18070. DOI: 10.1038/s41598-020-75232-0