3,4-Diphenyl-5H-furan-2-one

3,4-Diphenyl-5H-furan-2-one is a natural compound isolated from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius. 3,4-Diphenyl-5H-furan-2-one is a derivative of 2,3-diphenyltetrahydrofuran (DPTF), which is a COX-2 inhibitor. 3,4-Diphenyl-5H-furan-2-one can be used as a lead compound for inflammation and pain[1][2].

[1] Bai Z Q, et al. New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius[J]. Fitoterapia, 2014, 95: 194-202. DOI:10.1016/j.fitote.2014.03.021
[2] Singh P, et al. 2, 3-Diphenyltetrahydrofurans (DPTF)-A new class of stereogenic diarylheterocycles as potential COX-2 inhibitors-Computational evaluation of COX-2-DPTF binding behaviour[J]. 2006.