Ethyl 3-(N-methylamino) propionate

74-89-5

140-88-5

2213-08-3

1. cool 33% methylamine ethanol solution (100 mL, 805 mmol) in an ice bath at 0 °C. 2. Ethyl acrylate (11.0 mL, 10.1 g, 101 mmol) was added slowly, keeping the reaction temperature at 0 °C with continuous stirring for 2 hours. 3. Gradually warm the reaction mixture to room temperature and continue stirring for 15 minutes. 4. All volatiles were removed by distillation under reduced pressure. 5. The resulting residue (ethyl 3-(methylamino)propionate crude, 11.2 g) was used directly in the subsequent reaction without further purification.