Apigenin 7-O-Glucuronide hydrate

Apigenin 7-O-glucuronide is a flavonoid that has been found in J. sigillata and has diverse biological activities.1,2,3,4 It inhibits matrix metalloproteinase-3 (MMP-3), MMP-8, MMP-9, and MMP-13 (IC50s = 12.87, 22.39, 17.52, and 0.27 μM, respectively).1,2,3,4 Apigenin 7-O-glucuronide also inhibits protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), and aldose reductase with IC50 values of 7.14, 62.96, and 107.1 µM, respectively.2,3 It inhibits LPS-induced production of nitric oxide, prostaglandin E2 (PGE2; Item No. 14010), and TNF-α in RAW 264.7 cells when used at a concentration of 100 µM.4 Apigenin 7-O-glucuronide (5 or 10 mg/kg) improves survival in a mouse model of septic shock induced by LPS.WARNING This product is not for human or veterinary use.

[1] LUCIA CRASCÌ. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids.[J]. Planta medica, 2017, 83 11: 901-911. DOI: 10.1055/s-0043-104775
[2] DUC HUNG NGUYEN . Ellagitannin and flavonoid constituents from Agrimonia pilosa Ledeb. with their protein tyrosine phosphatase and acetylcholinesterase inhibitory activities[J]. Bioorganic Chemistry, 2017, 72: Pages 293-300. DOI: 10.1016/j.bioorg.2017.04.017
[3] NAM HEE YOO. Erigeroflavanone, a Flavanone Derivative from the Flowers of Erigeron annuus with Protein Glycation and Aldose Reductase Inhibitory Activity[J]. Journal of Natural Products , 2008, 71 4: 713-715. DOI: 10.1021/np070489a
[4] HU W, WANG X, WU L, et al. Apigenin-7-O-β-d-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock[J]. Food & Function, 2015, 2: 1002-1013. DOI: 10.1039/c5fo01212k