Acephate-d3 (N-Acetyl-d3)

Acephate-d3 is the deuterium labeled Acephate. Acephate is an anticholinesterase insecticide that produces cholinotoxicity. Acephate displays weak inhibition of rat AChE but potently inhibits cockroach AChE.

ChEBI: Acephate is a phosphoramide that is methamidophos in which one of the hydrogens is replaced by an acetyl group. It has a role as an acaricide, an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an agrochemical. It is a mixed diacylamine, a phosphoramide, an organic thiophosphate and an organothiophosphate insecticide. It is functionally related to a member of methamidophos.

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] A S ROJAKOVICK  R B M. In vitro and in vivo inhibition of house fly acetylcholinesterase by the N-acetyl phosphoramidothioate orthene.[J]. Journal of Economic Entomology, 1972, 65 5: 1505-1507. DOI: 10.1093/jee/65.5.1505a
[3] M A HUSSAIN  P C O  R B Mohamad. Studies on the toxicity, metabolism, and anticholinesterase properties of acephate and methamidophos.[J]. Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes, 1985, 20 1: 129-147. DOI: 10.1080/03601238509372472
[4] APURVA KUMAR R. JOSHI  P. S R. Reversible hyperglycemia in rats following acute exposure to acephate, an organophosphorus insecticide: Role of gluconeogenesis[J]. Toxicology, 2009, 257 1: Pages 40-45. DOI: 10.1016/j.tox.2008.12.006