Used in the preparation of pyranopyrazoles and pyrazolopyridines as AMPA receptor potentiators. Used in the preparation of methylsulfonamidomethylphenylpryidinylmethylpropanamide derivatives and analogs for use as vanilloid receptor ligands.Used in the preparation of amine substituted methanesulfonamide derivatives as vanilloid receptor ligands which is useful in treating diseases.Used in the preparation of pyrazolyl-based carboxamide and urea derivatives that are vanilloid receptor ligands useful in treatment and prophylaxis of pain and other diseases.Part of a fragment library targeting antibiotic resistance enzyme oxacillinase-48 including synthesis, structural evaluation and inhibitor design.