BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats[1].
BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats[1].
BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats[1].
| Animal Model: | Male Wistar rats (250-350 g) are ligated portal vein[1] |
| Dosage: | 0.1, 1 mg/kg |
| Administration: | A single i.v. |
| Result: | Significantly reduced shunt flow without affecting mesenteric flow. |
![D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- Structure](/CAS/20210111/GIF/693790-96-4.gif)
