Programmed cell death 1 ligand 2 (PD-L2), also known as B7-DC and CD273, is a B7 family protein that is involved in regulation and attenuation of the adaptive immune response.1,2 It is a 273-amino acid type I transmembrane protein encoded by the PDCD1LG2 gene in humans and is comprised of a 221-amino acid extracellular domain consisting of a signal peptide, an IgV-like domain, and an IgC-like domain, a transmembrane domain, and a cytoplasmic domain.3,4 PD-L2 is expressed in dendritic cells and macrophages and is induced by IL-4 and IFN-γ.1 Binding of PD-L2 to its receptor, programmed cell death protein 1 (PD-1), suppresses T cell proliferation and cytokine production.2 PD-L2 is also expressed in a variety of tumor types, and elevated expression of PD-L2 in tumor tissue is associated with decreased overall survival in patients with hepatocellular carcinoma.5,6 Cayman's PD-L2 Extracellular Domain (human, recombinant) protein can be used for ELISA and binding assay applications. This protein consists of 211 amino acids, has a calculated molecular weight of 24 kDa, an a predicted N-terminus of Leu20 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 40 to 45 kDa due to glycosylation.WARNING This product is not for human or veterinary use.
