CAY10729 (trifluoroacetate salt) (technical grade)

CAY10729 is a tetrazole derivative of the protein arginine deiminase (PAD) inhibitor Cl-amidine (Item No. 10599) that selectively inhibits PAD1 over PAD2, PAD3, and PAD4 (kinact/KI = 162,200, 60,000, 17,500, and 25,400 M-1min-1 for PAD1-4, respectively).1WARNING This product is not for human or veterinary use.

[1] VENKATARAMAN SUBRAMANIAN. Design, Synthesis, and Biological Evaluation of Tetrazole Analogs of Cl-Amidine as Protein Arginine Deiminase Inhibitors[J]. Journal of Medicinal Chemistry, 2015, 58 3: 1337-1344. DOI: 10.1021/jm501636x