3β-Cholic Acid-d4

3β-Cholic acid-d4 is intended for use as an internal standard for the quantification of 3β-cholic acid (Item No. 36447) by GC- or LC-MS. 3β-Cholic acid is a bile acid and an isomer of cholic acid (Item No. 20250).1 It has been found in human cecum and in postprandial urine samples from patients with non-alcoholic steatohepatitis (NASH).1,2WARNING This product is not for human or veterinary use.

[1] JAMES P HAMILTON. Human cecal bile acids: concentration and spectrum.[J]. American journal of physiology. Gastrointestinal and liver physiology, 2007, 293 1: G256-63. DOI: 10.1152/ajpgi.00027.2007
[2] KE LAN. Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids[J]. Analytical Chemistry, 2016, 88 14: 7041-7048. DOI: 10.1021/acs.analchem.6b00573