Octanamide, N-[2-(3,4-dihydroxyphenyl)ethyl]-

N-Octanoyl dopamine is superior to dopamine in protecting graft contractile function when administered to the heart transplant recipients from brain-dead donors. N-Octanoyl dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNγ-stimulated endothelial cells[1][2].

N-Octanoyl dopamine (NOD) protects cell cultures and tissues from cold storage inflicted damage. N-Octanoyl dopamine decreases lactate-dehydrogenase (LDH) release during cold storage of cardiomyocytes in vitro. NOD did not induce a significant elevation of intracellular cAMP and is devoid of dopaminergic and adrenergic action.

[1] Sivakkanan Loganathan, et al. N-octanoyl dopamine is superior to dopamine in protecting graft contractile function when administered to the heart transplant recipients from brain-dead donors. Pharmacol Res. 2019 Dec:150:104503. DOI:10.1016/j.phrs.2019.104503
[2] Bjrn B Hofmann, et al. N-Octanoyl-Dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNγ-stimulated endothelial cells. Sci Rep. 2019 Dec 18;9(1):19338. DOI:10.1038/s41598-019-55983-1