Heterogeneous nuclear ribonucleoprotein L belongs to a family of RNA binding multiprotein complexes that facilitate pre-mRNA processing and transport of mRNA from the nucleus to cytoplasm. hnRNP L binds to CA repeat elements to regulate splicing and RNA stability. Binding of hnRNP L has been shown to occur in response to stress stimuli to regulate conformational change and subsequent translation of mRNAs. hnRNPL can promote apoptosis by enhancing translation of p53 mRNA . In the context of tumor progression, hnRNPL has been shown to bind and modify translation of critical regulators of cell cycle and apoptosis.
[1] Piñol-Roma, S. et al. (1989) J Cell Biol 109, 2575-87.
[2] Dreyfuss, G. et al. (1993) Annu Rev Biochem 62, 289-321.
[3] Liu, X. and Mertz, J.E. (1995) Genes Dev 9, 1766-80.
[4] Hui, J. et al. (2003) RNA 9, 931-6.
[5] Hui, J. et al. (2005) EMBO J 24, 1988-98.
[6] Hung, L.H. et al. (2008) RNA 14, 284-96.
[7] Ray, P.S. et al. (2009) Nature 457, 915-9.
[8] Seo, J.Y. et al. (2017) Oncotarget 8, 51108-51122.
[9] Zhou, X. et al. (2017) Oncotarget 8, 19342-19353.
[10] Lv, D. et al. (2017) Oncotarget 8, 13586-13599.
