ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active[1].
References
[1] Ma H, et al. Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening. Eur J Med Chem. 2017 Jun 16;133:174-183. DOI:10.1016/j.ejmech.2017.03.076
