GGTI 298 is a CAAX peptidomimetic that selectively inhibits geranylgeranyltransferase I (GGTase I). It has been shown to arrest human tumor cells and induce apoptosis.
Definition
ChEBI: (2S)-2-[[[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-(1-naphthalenyl)phenyl]-oxomethyl]amino]-4-methylpentanoic acid methyl ester is a leucine derivative.
in vivo
The vivo mouse ileal loop experiments show fluid accumulation is reduced in a dose-dependent manner by TRAM-34, GGTI298, or H1152 when injected together with cholera toxin into the loop[1].
