(S)-(-)-BAY-K-8644
(S)-(-)-BAY-K-8644 用途与合成方法
EC50: 32 nM (I Ba )
(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca 2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and (S)-(-)-Bay-K-8644 as an agonist. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on I Ba in gastric myocytes of the guinea pig antrum. The Ca 2+ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca 2+ channels. The interactions of two Ca 2+ channel activators (S)-(-)-Bay-K-8644 and FPL 64176 is examined on smooth muscle L-type Ca 2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC 50 =14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca 2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176.
(S)-(-)-BAY-K-8644 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-11-08 | HY-15124 | 1 mg | 678 | ||
2024-11-08 | HY-15124 | (S)-(-)-BAY-K-8644 | 98625-26-4 | 5mg | 1350 |