(+)-16-m-Trifluoromethylphenoxy tetranor prostaglandin f2alpha-d4

Fluprostenol-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of fluprostenol by (Item No. 16768) GC- or LC-MS. Fluprostenol is a metabolically stable analog of prostaglandin F2α (PGF2α) with potent FP receptor agonist activity.1,2 It inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively.1,2 Fluprostenol is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 g/kg to terminate pregnancy.3 It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 value of 3-10 x 10−11 M.4WARNING This product is not for human or veterinary use.

[1] M. DUKES  A. L W  W RUSSELL. Potent luteolytic agents related to prostaglandin F2α[J]. Nature, 1974, 250 5464: 330-331. DOI: 10.1038/250330a0
[2] S. LAKE . Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor[J]. FEBS Letters, 1994, 355 3: Pages 317-325. DOI: 10.1016/0014-5793(94)01198-2
[3] MARK ABRAMOVITZS. Cloning and expression of a cDNA for the human prostanoid FP receptor.[J]. The Journal of Biological Chemistry, 1994, 18 1: 2632-2636. DOI: 10.1016/s0021-9258(17)41991-0
[4] GINETTE SERRERO  Nancy M L. Prostaglandin F2αReceptor (FP Receptor) Agonists Are Potent Adipose Differentiation Inhibitors for Primary Culture of Adipocyte Precursors in Defined Medium[J]. Biochemical and biophysical research communications, 1997, 233 1: Pages 200-202. DOI: 10.1006/bbrc.1997.6433