OSS_128167, is a selective SIRT6 inhibitor, showing immunosuppressive and chemosensitizing effects.
OSS_128167, is a selective SIRT6 inhibitor, showing immunosuppressive and chemosensitizing effects
eCll penetrant, potent and selective inhibitor of SIRT6.
OSS_128167 is a cell penetrant, potent and selective inhibitor of SIRT6 (Sirtuin 6) th at exhibits anti-cancer, anti-inflammatory, and anti-viral properties. OSS_128167 inhibits HBV transcription and replication through upregulating peroxisome proliferator-activated receptors α (PPARα) expression.
OSS_128167 (50 mg/kg; intraperitoneal injection; every 4 days; for 12 days; male HBV transgenic mice) treatment markedly suppresses the level of HBV DNA and 3.5-Kb RNA in HBV transgenic mice[2].
| Animal Model: | Male HBV transgenic mice (6-8-week-old)[2] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection; every 4 days; for 12 days |
| Result: | The level of HBV DNA and 3.5-Kb RNA were markedly suppressed in HBV transgenic mice.
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SIRT6: 89 μM (IC50); SIRT2: 751 μM (IC50); SIRT1: 1578 μM (IC50); HBV
