4,4-Bis(Ethoxycarbonyl)-1,2-dimethylcyclopentene is an intermediate in the synthesis of 3,4-Dimethyl-3-cyclopentene-1-carboxylic Acid (D615245), a useful intermediate for organic synthesis, used in the synthetic preparation of SAR, PPAR γ partial agonists with protein-tyrosine phosphatase 1B inhibition and antidiabetic activity of (S)-tetrahydroisoquinoline derivatives.