m-PEG3-S-PEG3-t-butyl ester

m-PEG3-S-PEG3-t-butyl ester is a PEG linker containing a t-butyl ester moiety. The t-butyl ester can be removed under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.

m-PEG3-S-PEG3-Boc is a PEG- and Alkyl/ether -based PROTAC linker can be used in the synthesis of PROTACs[1].

PEGs; Alkyl/ether

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005