AR-R17779 HYDROCHLORIDE
英文名称:AR-R 17779 hydrochloride
CAS号:178419-42-6
分子式:C9H15ClN2O2
分子量:218.68
EINECS号:
Mol文件:178419-42-6.mol
AR-R17779 HYDROCHLORIDE 性质
储存条件 | -20°C |
---|---|
溶解度 | <10.93mg/ml,溶于 DMSO; <21.87mg/ml,在水中 |
形态 | 粉末 |
颜色 | 白色至米色 |
旋光性 (optical activity) | [α]/D -59 to -69°, c = 1.0 in methanol |
AR-R17779 HYDROCHLORIDE 用途与合成方法
AR-R17779 hydrochloride 是一种有效和选择性的 nAChR 全激动剂,对 α7 和 α4β2 亚型的 Ki 直分别为 92 和 16000 nM。AR-R17779 hydrochloride 可以改善大鼠的学习和记忆能力。AR-R17779 hydrochloride 也具有抗焦虑活性。AR-R17779 hydrochloride 可通过激活抗炎胆碱能(迷走神经)途径减轻炎症。
IC50: 92 nM (α7-nAChR)
AR-R17779 is 5-fold more potent and 35000-fold more selective than (-)-nicotine for the α7 nicotinic receptor.
AR-R17779 (200 nM; 24 h) inhibits the LPS-induced TNF production in macrophages.
AR-R17779 (1-5 mg/kg; i.p. twice a day for 7 d) ameliorates arthritis, reduces synovial inflammation, delays onset of disease and protects against joint destruction.
AR-R17779 (1-10 mg/kg; s.c. for 3 weeks) improves learning in two radial-arm maze tasks and reverses working memory impairment caused by fimbria-fornix sections in rats.
Animal Model: | Male DBA/1 mice (8-10 weeks) were subjected to unilateral cervical vagotomy or sham surgery, after which arthritis was induced with type II collagen |
Dosage: | 1, 2.5, 5 mg/kg |
Administration: | I.p. twice daily from day 20 until day 26 |
Result: |
Ameliorated arthritis and delayed onset of disease.
Reduced erosive disease, cartilage degradation and synovial inflammation. Reduced TNFα levels in plasma and synovial tissue. |
AR-R17779 HYDROCHLORIDE供应商 更多
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
联系电话:021-61415566 800-8193336
产品介绍:
中文名称:AR-R17779 盐酸盐
英文名称:AR-R17779 Hydrochloride
CAS:178419-42-6
纯度:>=97% (HPLC)
包装信息:5MG
备注:SML2049-5MG
MedBio脉铂医药
联系电话:021-69568360 18916172912
产品介绍:
英文名称:AR-R 17779 hydrochloride
CAS:178419-42-6
纯度:98%
包装信息:10mg
备注:Medbio
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
英文名称:AR-R17779 hydrochloride
CAS:178419-42-6
纯度:97%
包装信息:5mg;10mg
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:化合物 AR-R 17779 hydrochloride
英文名称:AR-R 17779 hydrochloride
CAS:178419-42-6
纯度:98%
包装信息:50mg/RMB 13800;100mg/RMB 17500;25mg/RMB 10600
最新发布供应信息
化合物 AR-R 17779 hydrochloride|T21857|TargetMol
TargetMol中国(陶术生物)
2024-09-29
AR-R17779 盐酸盐,178419-42-6
西格玛奥德里奇(上海)贸易有限公司
2024-07-13