2′,3′-O-(2,4,6-Trinitrophenyl) adenosine 5′-triphosphate tetrasodium salt

TNP-ATP (2′,3′-O-(2,4,6-Trinitrophenyl) adenosine 5′-triphosphate) sodium salt has been used :

• To study its blocking effect on neck muscle electromyographic activity stimulated by application of α,β-meATP to the frontal dura.
• To study the effect of blocking purinergic receptors in response to hypercapnia.
• To study the role of P2X4 receptors in BDNF (brain-derived neurotrophic factor) induction in astrocytes.

TNP-ATP phosphate buffered solution is a stable, aqueous buffered solution of TNP-ATP, a purinoceptor P2X2/3 antagonist.

[1] C VIRGINIO. Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors.[J]. Molecular Pharmacology, 1998, 53 6: 969-973.
[2] PRISCA HONORE. TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics[J]. PAIN®, 2002, 96 1: Pages 99-105. DOI: 10.1016/s0304-3959(01)00434-1
[3] HONGBING YAO  Louis B H. Characterization of the binding of the fluorescent ATP analog TNP-ATP to insulysin[J]. Archives of biochemistry and biophysics, 2006, 451 2: Pages 175-181. DOI: 10.1016/j.abb.2006.04.011