α-N-acetylgalactosaminidase ((alpha-NaGalase) is an enzyme th at is encoded by the NAGA gene in humans. It is a lysosomal exoglycosidase th at cleaves terminal α-N-acetylgalactosamine residues from glycopeptides and glycolipids. Deficiency of α-NAGAL activity results in the lysosomal storage disorders Schindler disease and Kanzaki disease in humans. Its deficiency is a lysosomal disorder with clinically very different infantile and adult forms. α-NaGalase is accumulated in serum of cancer patients and is responsible for deglycosylation of Gc protein, which is a precursor of GcMAF-mediated macrophage activation cascade th at leads to immunosuppression in advanced cancer patients.
