LGD-2226

LGD-2226 is an orally active potent and selective androgen receptor modulator used in the treatment of muscle wasting and osteoporosis. Show to have an anabolic effect on muscle and bone tissue.

A 2 L round flask, under argon, was charged with a solution of the 14.00 g amine( 6-Amino-4-trifluoromethylquinolin-2(1H)-one )in 350 ml trifluoroacetic acid. 5.80 g NaBH4 was added within 1 h. The mixture was stirred at room temperature for 16 h. After that 4.50 g NaBH4 was added and then heated to 70°C for 5 h. The heating bath was removed and it was stirred at room temperature over 2 d. In several portions water was carefully added. In total 1500 ml water was slowly added. The yellow-greenish precipitate was filtered and rinsed with water. After drying, the crude product was purified by column chromatography on silica gel by using hexane-ethyl acetate (1:4), followed by a recrystallization in chloroform. 18.1 g of LGD-2226 was obtained as a bright yellow solid (76%).