25-?Cyclohexyl-?4''-?O-?de(2,?6-?dideoxy-?3-?O-?methyl-?α-?L-?arabino-?hexopyranosyl)?-?5-?O-?demethyl-?25-?de(1-?methylpropyl)?-Avermectin A1a is an intermediate in synthesizing 22,23-Didehydro Selamectin (D439445), an impurity of Selamectin (S247990) which is a topical parasiticide. Selamectin (S247990) is also used as a veterinary antihelminithic agent on animals.
Doramectin monosaccharide is an acid degradation product produced by selective hydrolysis of the terminal saccharide unit of doramectin. Doramectin monosaccharide is a potent inhibitor of nematode larval development, but is devoid of paralytic activity. Despite the importance of doramectin as an anthelmintic in animal health, there are no published reports of the biological activity or the levels of doramectin monosaccharide in animals or in the environment.