PD089828
PD089828 性质
| 密度 | 1.416±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：25mg/mL；乙醇：1mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.85±0.43(Predicted) |
| 颜色 | 白色至浅黄色 |
PD089828 用途与合成方法
|
FGFR1 0.15 μM (IC 50 ) |
PDGFR-β 1.76 μM (IC 50 ) |
EGFR 5.47 μM (IC 50 ) |
c-Src 0.18 μM (IC 50 ) |
FGFR1 0.14 μM (Ki) |
PDGFR-β 2.38 μM (Ki) |
EGFR 3.16 μM (Ki) |
c-Src 0.1 μM (Ki) |
PD-089828 (0.5-20 µM; 2 hours) inhibits PDGFR autophosphorylation with an IC
50
of 0.82 µM.
PD-089828 (1-50 µM; 2 hours) inhibits EGFR autophosphorylation with an IC
50
value of 10.9 µM.
In A121(p) cells, PD 089828 potently inhibits the phosphorylation of FGFR-1 with an IC
50
value of 0.63 µM.
PD-089828 (10 µM; 8 days) produces a concentration-related inhibition of serum-stimulated cell growth with an IC
50
value of 1.8 µM.
PD-089828 inhibits increases in DNA synthesis stimulated by all three growth factors, with IC
50
values of 0.8 for PDGF-, 1.7 for EGF- and 0.48 µM for bFGF-induced mitogenesis.
Cell Proliferation Assay
| Cell Line: | Vascular smooth muscle cells (serum-stimulated growth) |
| Concentration: | 10 µM |
| Incubation Time: | 8 consecutive days |
| Result: | Produced a concentration-related inhibition of serum-stimulated cell growth with an IC50 value of 1.8 µM. |
Western Blot Analysis
| Cell Line: | Vascular smooth muscle cells (stimulated with PDGF-BB 30 ng/ml) |
| Concentration: | 0.5-20 µM |
| Incubation Time: | 2 hours |
| Result: | Inhibited PDGFR autophosphorylation with an IC 50 of 0.82 µM. |
PD089828 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-112345 | 1 mg | 360 | ||
| 2024-11-08 | HY-112345 | PD089828 | 179343-17-0 | 5 mg | 900 |
