R 1530 is a multi-kinase inhibitor. It exhibits inhibitory activity against Chk2, KDR, FGFR, Aurora A kinase and Cdk2. It also binds VEGFR-2, FGFR1 and PDGFRβ. It displays antiproliferative activity in vitro and inhibits mitosis and angiogenesis.
R1530 is a multi-kinase inhibitor with activity against several kinases associated with tumor growth and angiogenesis, including VEGFR, FGFR, PDGFR, Chk2 and Cdk2. In tumor cells, R1530 inhibits tubulin polyerization and mitotic checkpoint function, resulting in polyploidy. The compound R1530 inhibits tumor growth and angiogenesis in animal models.
